178422-42-9 Usage
Description
Cefdinir Related Compound A (10 mg) (2(R)-2-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1Hfuro[3,4-d][1,3]thiazin-2-yl]acetic acid) is an impurity found in the synthesis of Cefdinir (C242670), a Cephalosporin antibiotic that is structurally similar to Cefixime (C242800). Cefdinir Related Compound A (10 mg) (2(R)-2-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1Hfuro[3,4-d][1,3]thiazin-2-yl]acetic acid) plays a role in the pharmaceutical industry, particularly in the development and production of antibiotics.
Uses
Used in Pharmaceutical Industry:
Cefdinir Related Compound A (10 mg) (2(R)-2-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1Hfuro[3,4-d][1,3]thiazin-2-yl]acetic acid) is used as an impurity in the synthesis process for the development of Cefdinir, a Cephalosporin antibiotic. The presence of this compound is important for understanding the synthesis process and ensuring the quality and efficacy of the final antibiotic product.
Check Digit Verification of cas no
The CAS Registry Mumber 178422-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,4,2 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 178422-42:
(8*1)+(7*7)+(6*8)+(5*4)+(4*2)+(3*2)+(2*4)+(1*2)=149
149 % 10 = 9
So 178422-42-9 is a valid CAS Registry Number.
178422-42-9Relevant articles and documents
Cefixime impurity and synthesis method thereof
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Paragraph 0046; 0050-0051; 0058; 0062-0063; 0070; 0074; 0075, (2020/10/04)
The invention discloses a cefixime impurity and a synthesis method thereof. The method comprises the following steps: a, hydrolyzing beta-lactam of cefdinir with alkali to obtain an intermediate 1; b,reacting acid with the intermediate 1 to obtain an intermediate 2; c, protecting amino of the intermediate 2 with Boc anhydride to obtain an intermediate 3; d, reacting the intermediate 3 with methylbromoacetate to obtain an intermediate 4; and e, deprotecting the intermediate 4 by using trifluoroacetic acid to obtain the target impurity. The synthetic reaction materials are easy to obtain, thecost is low, the reaction operation is simple, the reaction equipment requirement is not high, and the reaction condition is mild; the content of the synthesized target product is high, at present, the cefixime impurity is high in market price and cannot be bought, a relatively convenient and reliable obtaining channel is provided for research of cefixime impurities, the cost of the cefixime impurities is greatly reduced, and a great promotion effect is achieved for deeper and wider research of safety, reliability and stability of cefixime related drugs and quality control in the production process.
