178422-64-5Relevant academic research and scientific papers
Practical enantioselective synthesis of β-lactones catalyzed by aluminum bissulfonamide complexes
Kull, Thomas,Peters, Rene
, p. 1647 - 1652 (2007)
The development of an efficient and practical aluminum-bissulfonamide complex catalyzed enantioselective formation of β-lactones by [2+2] cycloaddition of ketene (generated in situ from acetyl bromide by dehydrobromination) with various α-unbranched and -
A synthesis of the hypocholesterolemic agent 1233A via asymmetric [2 + 2] cycloaddition
Dymock,Kocienski,Pons
, p. 1655 - 1661 (1998)
Key steps in a synthesis of the cholesterol biosynthesis inhibitor 1233A include: (a) asymmetric 1,4-reduction of an α,β-unsaturated ester using an enantiopure semicorrin (Pfaltz reduction); (b) a Cu(I)-mediated coupling of an iodoalkene and an alkenylstannane to generate a diene; (c) an asymmetric Lewis acid catalysed [2+2] cycloaddition of (trimethylsilyl)ketene to an aldehyde mediated by an enantiopure bis(sulfonamide) ligand.
