178430-13-2

Upstream product

• 178430-09-6 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 178429-67-9 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride 
• 259525-01-4 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine 
• 1256638-70-6 6-(4-fluorophenyl)-2-methylpyrimidine-4-carbonitrile 

Relevant academic research and scientific papers

Synthesis of 4-aryl and unsymmetrical 4,6-diarylpyrimidines by the Suzuki-Miyaura cross-coupling reaction

A two-step procedure for the synthesis of 4-arylpyrimidines from inexpensive 4,6-dichloropyrimidine via a Suzuki-Miyaura/hydrodechlorination reaction sequence is described. The reaction resulted in the predominant formation of mono-arylated product. The c

Pyrimidine as an Aryl C-H Activating Group

The Pd-catalyzed regioselective C-H activation/arylation, /iodination, and/acetoxylation reactions of 4-arylpyrimidines using aryl iodides, N-iodosuccinimide, and (diacetoxyiodo)benzene respectively as coupling partners are described. Suzuki-Miyaura coupl

PYRIMIDINE COMPOUND AND ITS USE IN PEST CONTROL

A pyrimidine compound represented by below formula (I) has excellent control activity against pests and is useful as an active ingredient of a pest controlling agent.

PROCESS FOR PRODUCING PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF

The present invention relates to a method for producing a pyrimidine derivative useful as a neurocyte necrosis inhibitor and an intermediate thereof. More particularly speaking, a method for producing an acid salt of 4-(4-fluorophenyl)-2-methyl-6-(5-piper

Derivatives of pyrimidine for treating acute cerebrovascular disorders

A pharmaceutical composition comprising a compound of the following general formula ?I! or its salt. STR1 wherein R1 represents aryl or a heteroaromatic group. R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R3 and R4 independently represent hydrogen or alkyl or R3 and R4 taken together with the adjacent N atom represent a 5- through 7-membered cyclic amino group. A represents C2-10 alkylene. W represents O, S, or (CH)n (where CH may be substituted by alkyl; n is an integer of 1 or 2). X, Y, and Z may be the same or different and each represents CH (which may be substituted by alkyl), or N. Provided, however, that the case in which X, Y, and Z concurrently represent CH is excluded. The compound of the invention has excellent neuronal death inhibitory activity and is useful as a therapeutic drug for cerebrovascular diseases.