178432-33-2Relevant academic research and scientific papers
A general and convenient synthesis of novel phosphotyrosine mimetics
Szardenings, Anna Katrin,Gordeev, Mikhail F.,Patel, Dinesh V.
, p. 3635 - 3638 (2007/10/03)
A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et3N/CBr4/HP(O)(OEt)2 provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.
