178446-93-0Relevant academic research and scientific papers
Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3- bis(hydroxymethyl)naphthalene lignans
Iwasaki, Tameo,Kondo, Kazuhiko,Kuroda, Tooru,Moritani, Yasunori,Yamagata, Shinsuke,Sugiura, Masaki,Kikkawa, Hideo,Kaminuma, Osamu,Ikezawa, Katsuo
, p. 2696 - 2704 (2007/10/03)
A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of the
