178476-48-7Relevant academic research and scientific papers
Synthesis and characterization of five-coordinate rhenium(V) and technetium(V) mixed ligand bifunctional complexes carrying the SNS/S or the SNN/S donor atom set.
Papadopoulos, Minas,Tsoukalas, Charalabos,Pirmettis, Ioannis,Nock, Berthold,Maina, Theodosia,Abedin, Zainul,Raptopoulou, Catherine P.,Terzis, Aris,Chiotellis, Efstratios
, p. 97 - 106 (2008/10/08)
Two parallel series of bifunctional mixed ligand oxorhenium and oxotechnetium complexes containing the SNS/S or the SNN/S donor atom set are synthesized and characterized in this study. The amine bifunctional anchor is positioned on the common monothiolate p-H2N-Ph-SH coligand, which by reacting in equimolar amounts with a tridentate aminethiolate ligand LH2 [LH2:CH3CH2N(CH2CH 2SH)2, (CH3CH2)2NCH2-CH 2N(CH2CH2SH)2, (CH2)4NCH2CH2NHCH2CH 2SH and (CH3CH2)2NCH2CH 2NH-CH2CH2SH] and the corresponding oxometal precursor, leads to the generation of these series. Two representative members ReO{[(C2H5)2NCH2CH 2N(CH2CH2S)2](p-H2N-PhS)} and ReO{[(CH2)4NCH2CH2NCH 2CH2S](p-H2N-PhS)} are further characterized by crystallographic analysis. The SNS/S analogs adopt a distorted trigonal bipyramidal geometry, while the SNN/S ones prefer a distorted square pyramidal geometry around the metal. Extrapolation of structure at tracer level is investigated by chromatographic methods and is established only for the SNS/S, but not for the SNN/S compounds. Thus, by this initial evaluation, the applicability of the bifunctional SNS/S (but not the SNN/S) system for tagging biomolecules with 99mTc is demonstrated.
