17853-46-2

Basic information

• Product Name: 1,8-Cyclohexadecanedione
• CAS NO: 17853-46-2
• Molecular Formula: C16H28O2
• Mol File: 17853-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-Cyclohexadecanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Cyclohexadecanedione(17853-46-2)
• EPA Substance Registry System: 1,8-Cyclohexadecanedione(17853-46-2)

Safety Data

• Hazardous Substances Data: 17853-46-2(Hazardous Substances Data)

Usage

Chemical structure

Cyclic musk compound

Usage

Fragrance ingredient in perfumes, colognes, and other scented products

Odor

Soft, sweet, musky with a warm, animalistic quality

Natural source

Musk glands of male musk deer

Production

Synthetically produced for commercial use

Studies

Potential as a pheromone, antimicrobial, and anti-inflammatory properties

Environmental impact

Concerns about its environmental impact

Health risks

Potential health risks associated with its use

Decline in use

Use in personal care products has declined in recent years due to environmental and health concerns

Upstream product

• 3100-36-5 (E/Z)-cyclohexa-dec-8-enone 

Relevant articles and documents

Selective Wacker type oxidation of a macrocyclic diene to the corresponding monounsaturated ketone used as fragrance

A selective reaction method for the efficient conversion of an isomeric mixture of 1,9-cyclohexadecadiene (1,9-CHDD) to the corresponding monounsaturated cyclohexadec-8-en-1-one (8-CHD) is described. 8-CHD was synthesized via Wacker type oxidation at room temperature using a highly electrophilic in situ formed dicationic palladium species. Isomerisation of the diene and over-oxidation of the substrate could be nearly suppressed by suitable reaction control, which has a positive effect on selectivity. The utilization of molecular oxygen as a green oxidant and environmentally benign iron(iii) salts as co-catalysts was successfully applied. This reaction strategy is promising to overcome the low overall reactivity of internal olefins in Wacker type oxidations. In addition, larger scale experiments showed further potential for industrial application.