178552-53-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 88793-42-4 2,2,2-trifluoro-N-[2-({2-[(trifluoroacetyl)amino]ethyl}amino)ethyl]acetamide 

Downstream Products

• 1040797-40-7 C₁₂H₁₉N₃O₂ 
• 178552-54-0 3,9-Bis(tert-butoxycarbonylmethyl)-6-benzyloxycarbonyl-3,6,9-triazaundecanedicarboxylic acid-di-tert-butyl ester 

Relevant academic research and scientific papers

Dynamic aggregation of the mid-sized gadolinium complex {Ph 4[Gd(DTTA)(H2O)2]- 3} Topical Issue on Metal-Based MRI Contrast Agents. Guest editor: Valerie C. Pierre

A compound binding three Gd3+ ions, {Ph4[Gd(DTTA) (H2O)2]- 3} (where H5DTTA is diethylenetriaminetetraacetic acid), has been synthesized around a hydrophobic center made up of fo

A benzene-core trinuclear GdIII complex: Towards the optimization of relaxivity for MRI contrast agent applications at high magnetic field

A novel ligand, H12L, based on a trimethylbenzene core bearing three methylenediethylenetriamine-N,N,N″,N″-tetraacetate moieties (-CH2DTTA4-) for Gd3+ chelation has been synthesized, and its trinuclear Gd3+ complex [Gd3L(H 2O)6]3- investigated with respect to MRI contrast agent applications. A multiple-field, variable-temperature 17O NMR and proton relaxivity study on [Gd3L(H 2O)6]3- yielded the parameters characterizing water exchange and rotational dynamics. On the basis of the 17O chemical shifts, bishydration of Gd3+ could be evidenced. The water exchange rate, kex298 = 9.0 ± 3.0 s-1 is around twice as high as kex298 of the commercial [Gd(DTPA)(H2O)]2- and comparable to those on analogous Gd3+-DTTA chelates. Despite the relatively small size of the complex, the rotational dynamics had to be described with the Lipari-Szabo approach, by separating global and local motions. The difference between the local and global rotational correlation times, τlO298 = 170 ± 10 ps and τgO298 = 540 ± 100 ps respectively, shows that [Gd3L(H2O)6]3- is not fully rigid; its flexibility originates from the CH2 linker between the benzene core and the poly(amino carboxylate) moiety. As a consequence of the two inner-sphere water molecules per Gd3+, their close to optimal exchange rate and the appropriate size and limited flexibility of the molecule, [Gd3L(H2O)6]3- has remarkable proton relaxivities when compared with commercial contrast agents, particularly at high magnetic fields (r1 = 21.6, 17.0 and 10.7 mM-1s -1 at 60, 200 and 400 MHz respectively, at 25 °C; r1 is the paramagnetic enhancement of the longitudinal water proton relaxation rate, referred to 1 mM concentration of Gd3+). The Royal Society of Chemistry.

Cascade polymer complexes, process for their production and pharamceutical agents containing said complexes

Cascade polymer complexes that contain a) complexing ligands of general formula I in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction

Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes

Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.

Process for the production of DTPA-monoamides of the central carboxylic acid and their use as pharmaceutical agents

A process for the production of of general formula I diethylenetriaminepentacarboxylic acid monoamide derivatives STR1 in which E1, E2 and Z have varying meanings.

Process for the production of DTPA-tetraesters of terminal carboxylic acids

The invention relates to a process for the production of diethylenetriaminepentacarboxylic acid tetraesters of general formula I STR1 in which R1 and Z have different meanings.