17859-41-5Relevant academic research and scientific papers
METHOD FOR PREPARING METHIONINE ANALOGUES
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Paragraph 0057-0067, (2020/09/22)
The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R1OOC—C(═X)—CHR2R3(I), wherein X is selected among O; N—R′, wherein R′ is H or a C1-C6 alkyl; and N—OR″ wherein R″ is H, or a C1-C6 alkyl or an alkylaryl; R1 is H or a C1-C6 alkyl group; R2 is H, a C1-C6 alkyl, or an alkylaryl; and R3 is CH2SR4 or CH2SeR4, where R4 is H or a C1-C6 alkyl from a compound (II), or one of the salts thereof, R1OOC—C(═X)—CHR2R5 and R5 is H or COOR6, where R6 is H or a C1-C6 alkyl, said method being carried out in the presence of a compound (III) CH2(Y)(Z). Wherein Y is H; OR7, where R7 is H, a C1-C6 alkyl or an acyl with formula CO—R4; SR4 or SeR4 where R4 matches the preceding definition; or 1 NR8R9, where R8 and R9, identical or different, each or together are a C1-C6 alkyl, or an alkylaryl; Z, identical or different to Y, is OR10 where R10 is H, a C1-C6 alkyl or CO—R4; a cyclic or acyclic N(COR4)(COR4) group; or NR11R12, where R11 and R12, identical or different, each or together are a C1-C6 alkyl or an alkylaryl; wherein Y and Z together are ═O; said method involving an intermediate product (IV) R1OOC—C(═X)—CHR2—CH2Z.
