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178603-78-6

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178603-78-6 Usage

Uses

Different sources of media describe the Uses of 178603-78-6 differently. You can refer to the following data:
1. Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]
2. Ac-YVAD-cmk has been used:as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulationas a caspase-1 inhibitor injected to C57BL/6 miceas a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injuryto abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

Check Digit Verification of cas no

The CAS Registry Mumber 178603-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,6,0 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 178603-78:
(8*1)+(7*7)+(6*8)+(5*6)+(4*0)+(3*3)+(2*7)+(1*8)=166
166 % 10 = 6
So 178603-78-6 is a valid CAS Registry Number.

178603-78-6 Well-known Company Product Price

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  • Sigma

  • (SML0429)  Ac-YVAD-cmk  ≥95% (HPLC)

  • 178603-78-6

  • SML0429-1MG

  • 910.26CNY

  • Detail
  • Sigma

  • (SML0429)  Ac-YVAD-cmk  ≥95% (HPLC)

  • 178603-78-6

  • SML0429-5MG

  • 3,672.63CNY

  • Detail

178603-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name AC-YVAD-CMK

1.2 Other means of identification

Product number -
Other names N-Ac-Tyr-Val-Ala-Asp-CMK

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:178603-78-6 SDS

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