178614-24-9Relevant academic research and scientific papers
Directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles with NaHMDS
Zhao, Hang,Dankwardt, John W.,Koenig, Stefan G.,Singh, Surendra P.
supporting information; experimental part, p. 166 - 169 (2012/01/30)
A mild and regioselective functionalization protocol for 3-bromofuran and analogs has been developed. Selective metalation and functionalization of C2 can be achieved as a result of the directing effect of the adjacent electron-withdrawing bromo group. In addition, the C5 position can also be selectively functionalized by blocking the C2 position via silylation or by simply controlling the reaction temperature. These functionalized compounds bearing a C3 bromo substituent may be further elaborated by utilizing a Suzuki-Miyaura cross-coupling procedure.
Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
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, (2008/06/13)
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
