178616-26-7

Basic information

• Product Name: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
• Synonyms: CFM-2;1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE;4H-2,3-Benzodiazepin-4-one,1-(4-aminophenyl)-3,5-dihydro-7,8-dimethoxy-
• CAS NO: 178616-26-7
• Molecular Formula: C₁₇H₁₇N₃O₃
• Molecular Weight: 311.34
• Product Categories: Glutamate receptor
• Mol File: 178616-26-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.32g/cm³
• Storage Temp.: Store at RT
• CAS DataBase Reference: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE(178616-26-7)
• EPA Substance Registry System: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE(178616-26-7)

Safety Data

• Hazardous Substances Data: 178616-26-7(Hazardous Substances Data)

Usage

Uses

CFM-2 is a non-competitive antagonist of the AMPA receptors.

Biological Activity

Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 187940-06-3 [4,5-Dimethoxy-2-(4-nitro-benzoyl)-phenyl]-acetic acid 
• 92774-40-8 3,4-dihydro-6,7-dimethoxy-1-(4-nitrophenyl)-1H-isochromene 
• 187940-12-1 7,8-Dimethoxy-1-(4-nitro-phenyl)-3,5-dihydro-benzo[d][1,2]diazepin-4-one 

Relevant articles and documents

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodeg