178634-04-3

Basic information

• Product Name: (+)-trans-3-(4-hydroxyphenoxymethyl)-1-methyl-4-phenylpiperidine
• CAS NO: 178634-04-3
• Molecular Weight: 297.397
• Mol File: 178634-04-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-trans-3-(4-hydroxyphenoxymethyl)-1-methyl-4-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-trans-3-(4-hydroxyphenoxymethyl)-1-methyl-4-phenylpiperidine(178634-04-3)
• EPA Substance Registry System: (+)-trans-3-(4-hydroxyphenoxymethyl)-1-methyl-4-phenylpiperidine(178634-04-3)

Safety Data

• Hazardous Substances Data: 178634-04-3(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 

Downstream Products

• 54088-36-7 (+)-trans-3-(3,4-methylenedioxyphenoxymethyl)-4-phenylpiperidine hydrochloride 
• 176022-02-9 (+)-trans-3-hydroxymethyl-1-methyl-4-phenylpiperidine 

Relevant articles and documents

Synthesis and 5HT modulating activity of stereoisomers of 3-phenoxymethyl-4-phenylpiperidines

A series of pairs of enantiomers of substituted 3-phenoxymethyl-4-phenylpiperidines has been prepared from arecoline or α-methylstyrene by a combination of stereospecific reactions and optical resolutions. The ability of the compounds to modulate serotonin (5HT) neurotransmission in vitro was determined. Several derivatives, among which is the antidepressant paroxetine, are very potent inhibitors of 5HT reuptake. These compounds exhibit a pronounced steric requirement for inhibition of 5HT reuptake and binding to 5HT2A and 5HT2C receptors. Acta Chemica Scandinavica 1996.