178666-09-6Relevant articles and documents
Synthesis and sar of dhodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands
Curtis, Neil R.,Kulagowski, Janusz J.,Leeson, Paul D.,Mawer, Ian M.,Ridgill, Mark P.,Rowley, Michael,Grimwood, Sarah,Marshall, George R.
, p. 1145 - 1150 (2007/10/03)
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety. Copyright