178671-81-3Relevant articles and documents
β-, γ- and δ-Lactams as conformational constraints in ring-closing metathesis
Tarling, Chris A.,Holmes, Andrew B.,Markwell, Roger E.,Pearson, Neil D.
, p. 1695 - 1701 (2007/10/03)
The azabicycloalkenones 5, 6 and 7 were formed in excellent yields via ring-closing metathesis of the bis-alkenyl precursors 1, 2 and 3.
Novel route to fused nitrogen heterocycles by olefin metathesis
Martin, Stephen F.,Liao, Yusheng,Chen, Hui-Ju,Paetzel, Michael,Ramser, Melissa N.
, p. 6005 - 6008 (2007/10/02)
A novel technique for the efficient synthesis of fused nitrogen heterocycles has been developed that features the molybdenum alkylidene-catalyzed metathesis of α,ω-dienes containing a nitrogen atom in the chain linking the two olefinic functional groups. The starting materials may be readily prepared in three steps from succinimide and glutarimide via sequential Mitsunobu alkylation, sodium borohydride reduction, and addition of a vinyl cuprate to an N-acyliminium salt generated in situ.
