178685-40-0Relevant academic research and scientific papers
The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins
Angus, Donald I.,Kiefel, Milton J.,Von Itzstein, Mark
, p. 2709 - 2718 (2007/10/03)
The intimate involvement of carbohydrate-protein interactions in a number of important biological processes has prompted several research efforts towards developing new methods of investigating these glycobiological interactions. Biotinylated oligosaccharides are emerging as a new and powerful tool in this area of research, primarily due to their high affinity towards streptavidin and their ease of immobilization on matrices. Here we describe a novel synthetic approach towards biotinylated saccharides which incorporate a UV absorbing group into the final compounds. The synthetic strategy described is applicable to a variety of saccharides, with examples of biotinylated mono-, di-, and trisaccharides being prepared with overall high efficiency. Copyright (C) 2000 Elsevier Science Ltd.
