178687-20-2

Basic information

• Product Name: Cyclopropanecarboxylic acid, 2-(chlorocarbonyl)-, ethyl ester (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 2-(chlorocarbonyl)-, ethyl ester (9CI)
• CAS NO: 178687-20-2
• Molecular Formula: C₇H₉ClO₃
• Molecular Weight: 176.59756
• Product Categories: ACIDHALIDE
• Mol File: 178687-20-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 2-(chlorocarbonyl)-, ethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 2-(chlorocarbonyl)-, ethyl ester (9CI)(178687-20-2)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 2-(chlorocarbonyl)-, ethyl ester (9CI)(178687-20-2)

Safety Data

• Hazardous Substances Data: 178687-20-2(Hazardous Substances Data)

Upstream product

• 167113-73-7 D,L-Trans-2-Ethoxycarbonylcyclopropane-1-carboxylic acid 

Downstream Products

• 194206-02-5 methyl N^α-benzyloxycarbonyl-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-orthinate 
• 194206-09-2 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate 
• 1055036-70-8 2-((S)-4-Benzyloxycarbonylamino-4-carboxy-butylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester 

Relevant articles and documents

Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid

The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.