178737-10-5

Basic information

• Product Name: Cyclohexanemethanol, 2-amino-, (1R,2R)- (9CI)
• Synonyms: Cyclohexanemethanol, 2-amino-, (1R,2R)- (9CI);(1R,2R)-1-aMino-2-hydroxyMethyl-cyclohexane
• CAS NO: 178737-10-5
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Product Categories: AMINEPRIMARY
• Mol File: 178737-10-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexanemethanol, 2-amino-, (1R,2R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanemethanol, 2-amino-, (1R,2R)- (9CI)(178737-10-5)
• EPA Substance Registry System: Cyclohexanemethanol, 2-amino-, (1R,2R)- (9CI)(178737-10-5)

Safety Data

• Hazardous Substances Data: 178737-10-5(Hazardous Substances Data)

Upstream product

• 26693-58-3 (-)-(R,R)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid 
• 5691-19-0 (1R,2R)-2-aminocyclohexanecarboxylic Acid 
• 16524-13-3 (+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid 
• 163877-12-1 (R,R,R)-2--1-carbethoxycyclohexane 
• 163705-86-0 (1S,2R,αR)-2--1-carbethoxycyclohexane 
• 121506-74-9 ethyl (-)-N-<(R)-1-phenylethyl>-1-aminocyclohexene-2-carboxylate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 178112-24-8 [(1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclohexyl]-methanol 
• 26849-62-7 trans-2-amino-1-cyclohexyl carboxylic acid ethyl ester 

Downstream Products

• 29569-80-0 (1R,2S)-2-(hydroxymethyl)cyclohexanol 
• 213672-84-5 trans-(1R,2R)-1-(benzyloxycarbonylamino)-2-hydroxymethyl-cyclohexane 
• 383430-26-0 {(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-carbamic acid benzyl ester 
• 275815-63-9 (1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexylamine 
• 275815-60-6 (1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde 
• 852660-37-8 N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea 
• 852660-52-7 N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea 
• 852660-57-2 N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)urea 
• 852660-35-6 (1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester 
• 852660-55-0 benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate 
• 852660-58-3 benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate 
• 852660-49-2 (2-{[3-(4-fluorophenyl)-2,2-dimethylpropylamino]methyl}cyclohexyl)-carbamic acid benzyl ester 
• 852660-40-3 (1R,2S)-[2-({[3-(4-fluoro-phenyl)-propyl]-methyl-amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester 
• 852660-36-7 (1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Stereoselective process for a CCR3 antagonist

A convergent, multikilogram, stereoselective synthesis of 1 is described. A key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from valerolactam in three steps using our recently discovered Ir-BDPP-catalyzed asymmetric hydrogenation. Anoth