17874-62-3

Basic information

• Product Name: 1-propylpiperidine hydrochloride (1:1)
• Synonyms: Diphenidol Impurity 7 HCl;1-Propylpiperidine Hydrochloride
• CAS NO: 17874-62-3
• Molecular Formula: C₈H₁₈ClN
• Molecular Weight: 163.6882
• Mol File: 17874-62-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 151.6°C at 760 mmHg
• Flash Point: 39.8°C
• Vapor Pressure: 3.63mmHg at 25°C
• CAS DataBase Reference: 1-propylpiperidine hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-propylpiperidine hydrochloride (1:1)(17874-62-3)
• EPA Substance Registry System: 1-propylpiperidine hydrochloride (1:1)(17874-62-3)

Safety Data

• Hazardous Substances Data: 17874-62-3(Hazardous Substances Data)

Usage

Description

1-Propylpiperidine hydrochloride (1:1) is a chemical compound derived from the organic heterocyclic amine, Piperidine (P479985). It is an impurity found in the synthesis of various organic compounds, including pharmaceuticals, where Piperidine serves as a building block and reagent.

Uses

Used in Pharmaceutical Industry:
1-Propylpiperidine hydrochloride (1:1) is used as a precursor in the synthesis of pharmaceuticals for its potential role in the development of new drugs and medicinal compounds. Its presence as an impurity in Piperidine indicates its involvement in the creation of diverse organic compounds that can be utilized in the medicinal field.

Upstream product

• 57147-14-5 N-Propyl-1,4-dihydropyridin 

Downstream Products

• 75200-63-4 5-Methyl-2,6-diphenyl-3-[4-(3-piperidin-1-yl-propoxy)-phenyl]-furo[3,2-g]chromen-7-one 

Relevant articles and documents

On the Mechanism of Protein Crosslinking with Glutaraldehyde

The interaction of glutaraldehyde with model aliphatic amines was studied in order to understand the crosslinking reaction of glutaraldehyde with proteins.The reaction in organic solvents gave N-alkyl-1,4-dihydropyridines and N,N'-dialkyl-1,5-diiminopentanes.The isolated products are new or were previously described by us for the first time.Hydration of the reaction products led to stable N-alkylpiperidines and N,N'-dialkyl-1,5-diaminopentanes.In aqueous solution the reaction dependens on the pH: at a pH above 7, N-alkyl-1,4-dihydropyridines and at a pH below 7, polym ers were obtained.For the crosslinking reaction of proteins with glutaraldehyde the following mechanism is proposed: Monomeric glutaraldehyde reacts with the protein to give intermediate N-alkyl-2,6-dihydroxypiperidines.Intramolecular dehydration leads to the corresponding N-alkyl-1,4-dihydropyridines.Condensation of the cyclic monohydrate of glutaraldehyde and N-alkyl-2,6-dihydroxypiperidines gives linear polymeric crosslinks containing α-oxo-N-alkylpiperidine units. - Keywords: Crosslinking mechanism; N-Alkyl-1,4-dihydropyridines; N,N'-Alkyl-1,5-diiminopentanes