178747-83-6

Basic information

• Product Name: 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)
• Synonyms: 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI);4-Fluorobenzo[d]isoxazol-3(2H)-one;4-fluorobenzo[d]isoxazol-3-ol;4-Fluoro-1,2-benzisoxazol-3(2H)-one
• CAS NO: 178747-83-6
• Molecular Formula: C7H4FNO2
• Molecular Weight: 153.1105632
• Product Categories: HALIDE;OXAZOLE
• Mol File: 178747-83-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 201-205℃
• Appearance: /
• Density: 1.440±0.06 g/cm3 (20℃ 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)(178747-83-6)
• EPA Substance Registry System: 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)(178747-83-6)

Safety Data

• Hazardous Substances Data: 178747-83-6(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI) is an organic compound with the molecular formula C8H5NO2F. It is a derivative of benzisoxazolone, and its chemical structure contains a benzene ring fused to an isoxazole ring. The presence of a fluorine atom at the 4th position of the benzisoxazolone ring gives the compound its unique properties. This chemical is used in various pharmaceutical and medicinal applications, particularly in the development of new drugs and pharmaceutical compounds. Its specific properties and interactions with biological targets make it an interesting molecule for further research in the field of medicinal chemistry and drug development.

Upstream product

• 1034249-02-9 C₁₇H₁₆FNO₅ 
• 855996-64-4 2-fluoro-N,6-dihydroxybenzamide 
• 72373-81-0 Methyl 2-fluoro-6-hydroxybenzoate 
• 67531-86-6 6-fluorosalicylic acid 
• 125309-34-4 2,6-difluoro-N-hydroxybenzamide 

Downstream Products

• 1331782-39-8 (R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate 

Relevant articles and documents

(R)-4-((4-((4-(TETRAHYDROFURAN-3-YLOXY)BENZO[D]ISOXAZOL-3-YLOXY)METHYL)PIPERIDIN-1-YL)METHYL)TETRAHYDRO-2H-PYRAN-4-OL, A PARTIAL AGONIST OF 5-HT4 RECEPTORS

(R)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3- yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol and its use in treating neurodegenerative disorders, is described herein.

Benzo[d]isoxazol-3-ol DAAO inhibitors

Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutic amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein Z1 is N or CR3; Z2 is N or CR4; Z3is O or S; A is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof; R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, hydroxy alkoxy, aryl, acyl, halo, cyano, haloalkyl, NHCOOR5 and SO2NH2; R5 is aryl, arylalkyl, heteroaryl or heteroarylalkyl; at least one of R1, R2, R3 and R4 is other than hydrogen; and at least one of Z1 and Z2 is other than N.

Isoxazole derivatives

An isoxazole compound having the following formula: wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.