178757-08-9

Upstream product

• 178757-06-7 Acetic acid (R)-2-(2-oxo-3,4-dihydro-2H-pyridin-1-yl)-2-phenyl-ethyl ester 
• 152555-04-9 Acetic acid (R)-2-(2,6-dioxo-piperidin-1-yl)-2-phenyl-ethyl ester 
• 178899-98-4 (S)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methylsulfanyl-piperidin-2-one 

Downstream Products

• 178757-09-0 (3R,5S)-3-Azido-1-((R)-2-hydroxy-1-phenyl-ethyl)-5-methylsulfanyl-piperidin-2-one 
• 178900-00-0 2-[(3S,5S)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-5-methylsulfanyl-2-oxo-piperidin-3-yl]-isoindole-1,3-dione 

Relevant academic research and scientific papers

Conformationally restricted analogues of methionine: Synthesis of chiral 3-amino-5-methylthio-2-piperidones

(αR, 3RS, 5S)-3-Amino-N-(2-hydroxy-1-phenylethyl)-5-methylthio-2- piperidones 1 have been synthesized from enamide 2 by subsequent free radical addition of methanothiol on position 5 and amination of 3-position.