17879-89-9Relevant articles and documents
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McNutt
, p. 217,221 (1960)
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Trioxopteridine derivatives suitable as medicament
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, (2008/06/13)
Trioxopteridine derivatives of the formula STR1 , wherein R1 is a normal alkyl group having 0 to 6 hydroxyl groups and R2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R2 --A--COOR3, wherein R3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula STR2 wherein R4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.