17880-62-5

Usage

Uses

Used in Pharmaceutical Industry:
(4-METHYL-QUINOLIN-2-YLSULFANYL)-ACETIC ACID is used as a potential pharmaceutical compound for its possible anti-inflammatory and antimicrobial effects, which are characteristic of quinoline derivatives. Its unique structure with a sulfur atom and a methyl group may contribute to its therapeutic properties.
Used in Organic Synthesis:
(4-METHYL-QUINOLIN-2-YLSULFANYL)-ACETIC ACID is used as a precursor or intermediate in the synthesis of other organic compounds, particularly due to the presence of the acetic acid group, which can be utilized in various chemical reactions to produce a range of products.

InChI:InChI=1/C12H11NO2S/c1-8-6-11(16-7-12(14)15)13-10-5-3-2-4-9(8)10/h2-6H,7H2,1H3,(H,14,15)

Upstream product

• 22977-70-4 2-allylthio-4-methylquinoline 
• 107456-14-4 (4-methyl-2-quinolylthio)acetic acid ethyl ester 
• 4437-65-4 4-methyl-2-thioxo-1H-quinoline 
• 79-11-8 chloroacetic acid 
• 4437-65-4 2-mercapto-4-methylquinoline 

Downstream Products

• 74862-02-5 2-phenylmercaptocarbamoyl-5-methylthiazolo<3,2-a>quinolinium 1-oxide 

Relevant academic research and scientific papers

Synthesis of derivatives of (4-methyl-2-quinolylthio)acetic and (4-methyl-2-quinolylthio)propionic acids

An efficient synthesis has been developed for derivatives of (4-methyl-2-quinolylthio)acetic and (4-methyl-2-quinolylthio)propionic acids by the reaction of 4-methyl-2-thioxoquinoline with methyl methacrylate, the amide of methacrylic acid, acrylonitrile, ethyl bromoacetate, and ethyl acrylate. The hydrolysis of the resultant intermediates by (quinolylthio)acetic and (quinolylthio)propionic acids gave the corresponding acid products, which are also formed in the reaction of 4-methyl-2-thioxoquinoline with chloroacetic and acrylic acids. The reaction of 4-methyl-2-thioxoquinoline with allyl bromide was studied. The potassium permanganate oxidation of the resultant 2-allylthio-4-methylquinoline led to (4-methyl-2-quinolylthio)acetic acid.

Four- and five-coordinate metal atoms in a supramolecular polymeric assembly of silver(I) with (4-methyl-2-quinolylthio)acetate

The coordination compound [Ag2L2(H2O)2] · 2H2O (I), L = C12H10NO2S has been synthesized by the reaction of AgNO3 with 4-methyl-2-quinolylthioacetic acid (HL) preliminarily neutralized with an equimolar amount of NBu4OH. Its crystal structure has been determined, and luminescence properties have been studied. Crystals of I are monoclinic, space group C2/c, a = 31.239(6) ?, b = 12.056(2) ?, c = 16.846(3) ?, β = 122.17(3)°, V = 5370.4(2) ?3, ρcalc = 1.861 g/cm3, Z = 16. The structure is formed by two crystallographically nonequivalent silver atoms Ag(1) and Ag(2) and two tridentate bridging ligands L coordinated through the S, N, and O atoms. These atoms, together with water molecules, form the coordination environments of the metal atoms with CN = 5 and 4, respectively. The Ag+ ions and the tridentate ligands form infinite [Ag4L4]n bands extended in the [001] direction. The presence of outer-sphere water molecules involved in O–H···O hydrogen bonding is responsible for the formation of a supramolecular framework structure. The photoluminescence spectrum of compound I shows two bands at ~450 and ~485 nm corresponding to the blue spectral range.