1789-25-9Relevant academic research and scientific papers
Synthesis of heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anticancer drugs: Part I
Abdel-Rahman, Reda M.,Morsy,Hanafy,Amene
, p. 347 - 351 (2007/10/03)
Some new heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety (3-22) have been achieved by treatment of 3-amino-5,6-disubstituted- 1,2,4-triazines 2a-h with some cyclic and acyclic oxygen compounds followed by heterocyclization. Structures of the products have been deduced by elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of the series, where compounds 5 and 18 showed a moderate activity.
Reaction of 3-Amino-5,6-dimethyl-1,2,4-triazine with Electrophiles
Suzuki, Toshinobu,Okazaki, Masahiko,Mitsuhashi, Keiryo
, p. 935 - 939 (2007/10/02)
The title compound was reacted with four types of electrophiles and the respective reaction sites were investigated.The reaction with aryl isocyanates in the conventional way yielded the corresponding ureas.In the presence of triethylamine, the 3-amino gr
