17890-64-1

Basic information

• Product Name: 2-Hydroxy-α,α-diethylbenzyl alcohol
• Synonyms: 2-Hydroxy-α,α-diethylbenzyl alcohol
• CAS NO: 17890-64-1
• Molecular Weight: 180.247
• Mol File: 17890-64-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-α,α-diethylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-α,α-diethylbenzyl alcohol(17890-64-1)
• EPA Substance Registry System: 2-Hydroxy-α,α-diethylbenzyl alcohol(17890-64-1)

Safety Data

• Hazardous Substances Data: 17890-64-1(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 74-96-4 ethyl bromide 
• 119-36-8 methyl salicylate 

Downstream Products

• 10277-99-3 2-(1-ethyl-propenyl)-phenol 
• 80751-97-9 o-(1-ethylpropyl)phenol 
• 17890-69-6 α,α,N-Triaethyl-o-hydroxy-benzylamin 
• 17890-68-5 N-Acetyl-α,α-diaethyl-o-hydroxy-benzylamin 
• 55709-93-8 2-Diethylaminomethyl-4,4-diethyl-4H-1,3-benzoxazine hydrochloride 
• 27412-20-0 2-benzyl-4,4-diethyl-4H-benzo[e][1,3]oxazine 
• 27507-92-2 2-(4-chloro-phenyl)-4,4-diethyl-4H-benzo[e][1,3]oxazine 

Relevant articles and documents

Improved Synthesis of MediPhos Ligands and Their Use in the Pd-Catalyzed Enantioselective N-Allylation of Glycine Esters

A new class of chiral C2-symmetric diphosphines (MediPhos) was recently shown to give superior results in the Pd-catalyzed asymmetric N-allylation of amino acid esters. We here describe a new, improved protocol for the preparation of such ligands through bidirectional SN2-coupling of a tartrate-derived ditosylate with 6-alkyl-2-bromophenols followed by double lithiation/phosphanylation. This method gave access to a series of nine ligands with branched alkyl substituents, which were benchmarked in the enantioselective Pd-catalyzed N-allylation of tert-butyl glycinate with racemic (E)-2,8-dimethylnona-5-en-4-yl methyl carbonate (up to 95 % ee). In addition, the analogous transformation of tert-butyl glycinate with methyl (E)-nona-5-en-4-yl carbonate was optimized. The obtained allylic amines were then used in the stereoselective synthesis of the conformationally restricted proline-derived dipeptide analogs ProM-17 and ProM-21.