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Usage

Uses

Used in Food Industry:
2-Amino-3-cyano-5-methylpyrazine is used as a flavoring agent for adding a roasted and nutty flavor to various food products, enhancing the taste and aroma of the final product.
Used in Pharmaceutical Production:
2-Amino-3-cyano-5-methylpyrazine is utilized in the production of pharmaceuticals, where its unique chemical structure contributes to the development of new drugs with potential therapeutic benefits.
Used in Agrochemicals:
2-Amino-3-cyano-5-methylpyrazine is also used in the production of agrochemicals, where it may contribute to the development of new pesticides or other agricultural products.
Used in Medicinal Applications:
2-Amino-3-cyano-5-methylpyrazine has been studied for its potential antioxidant and anti-inflammatory properties, making it a promising candidate for various medicinal applications, such as the development of new treatments for inflammatory diseases or conditions related to oxidative stress.
However, it is crucial to handle 2-Amino-3-cyano-5-methylpyrazine with care, as it may have harmful effects if not used properly, highlighting the importance of safety measures in its application across different industries.

Upstream product

• 74290-65-6 2-amino-3-bromo-5-methylpyrazine 
• 820250-28-0 3-amino-6-methyl-pyrazine-2-carboxylic acid amide 
• 73198-27-3 2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 1-oxide 
• 73198-31-9 2-Amino-6-(carbomethoxy)-3-cyano-5-methylpyrazine 

Relevant academic research and scientific papers

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.

Studies on Pyrazines; Part 20. A Simple Synthesis of 5-Substituted 2-Amino-3-cyanopyrazines: Useful Intermediates for Pteridine Synthesis

A new and convenient synthesis of 5-substituted 2-amino-3-cyanopyrazines 3 involving cyanation of the corresponding 2-amino-3-bromopyrazines 2 with sodium dicyanocuprate is reported.

Pteridines. 47. Preparation and Chemistry of 2-Amino-6-carbalkoxy-3-cyano-5-substituted Pyrazine 1-Oxides: Synthesis of Pterin-6-carboxaldehyde

A new procedure for the synthesis of 2-amino-3-cyano-5-substituted pyrazines 9, useful intermediates for the synthesis of pteridines, is described.Oximation of β-keto esters 2 followed by reaction with aminomalononitrile provides 2-amino-6-carbalkoxy-3-cyano-5-substituted pyrazine 1-oxides 5.Protection of the amino group as its ((dimethylamino)methylene)amino derivative 9 followed by SN2 decarbalkoxylation provides pyrazines 10 which on removal of the protecting group and deoxygenation give pyrazines 8.This method is designed to be of use in cases where the β-keto ester cannot be converted directly to the corresponding α-keto aldoxime 3.The procedure is applied to the synthesis of 2-amino-3-cyano-5-(dimethoxymethyl)pyrazine (8a), an intermediate in the synthesis of pterin-6-carboxaldehyde (1).