17892-92-1Relevant academic research and scientific papers
Synthesis and antifungal activity of 2-(4-chlorophenylcarbamoyl)phenyl acetate
Tang, Xiaorong,Feng, Hui,Du, Quan,Wang, Ling
, p. 7271 - 7273 (2013)
2-(4-Chlorophenylcarbamoyl)phenyl acetate was synthesized by the ammonolysis of 2-(chlorocarbonyl)phenyl acetate. Its structure was confirmed by IR and 1H NMR. Its antifungal activity against Sclerotinia sclerotiorum and Helminthosprium maydis has been de
Synthesis and antifungal activity of aspirin derivatives
Gao, Sumei,Xu, Zhihong,Wang, Xuesong,Feng, Hui,Wang, Ling,Zhao, Yuanjiang,Wang, Yue,Tang, Xiaorong
, p. 7157 - 7159 (2015/04/22)
Using aspirin as a lead compound, a series of its derivatives (compounds 1-7) were designed and synthesized. Their activity of antipathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea and Rhizoctonia solani. Among them, the inhibition of growth for compounds 1 and 2 against Helminthosprium maydis reached 92.5 and 91.6% at a concentration of 100 mg L-1, respectively, which was superior to carbendazim.
Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides-potent inhibitors of type III secretion in Yersinia
Dahlgren, Markus K.,Kauppi, Anna M.,Olsson, Ing-Marie,Linusson, Anna,Elofsson, Mikael
, p. 6177 - 6188 (2008/09/16)
Analogues to the salicylanilide N-(4-Chlorophenyl)-2-acetoxy-3,5- diiodobenzamide, 1a, an inhibitor of type III secretion (T3S) in Yersinia, were selected, synthesized, and biologically evaluated in three cycles. First, a set of analogues with variations in the salicylic acid ring moiety was synthesized to probe possible structural variation. A basic structure-activity relationship was established and then used to cherry-pick compounds from a principal component analysis score plot of salicylanilides to generate a second set. A third set with increased likelihood of biological activity was designed using D-optimal onion design. A quantitative structure-activity relationship model using hierarchical partial least-square regression to latent structures (Hi-PLS) was computed using PLS score vectors of building blocks correlated to the % inhibition of T3S as a response. A PLS discriminant analysis (PLS-DA) model was derived using the same descriptor set as that for the Hi-PLS model. Both models were validated with an external test set.
