178924-20-4Relevant academic research and scientific papers
A diketopyrrolopyrrole-based low bandgap polymer with enhanced photovoltaic performances through backbone twisting
Wen, Shuguang,Chen, Weichao,Fan, Meijie,Duan, Linrui,Qiu, Meng,Sun, Mingliang,Han, Liangliang,Yang, Renqiang
, p. 18174 - 18180 (2016)
A diketopyrrolopyrrole (DPP)-based π-conjugated polymer is a very promising low band gap electron donor material for polymer solar cells. We have incorporated alkyl groups into the 4-position of the thiophene rings connected to the DPP fragment, which is proven to be beneficial for improving the open-circuit voltage (VOC) and short-circuit current density (JSC). Two DPP-based polymers are synthesized with benzo[1,2-b:4,5-b′]dithiophene (BDT) as the electron-donating segment. Both the polymers show good solubility, slightly wide optical band gaps and deep HOMO energy levels when incorporating the alkyl groups. Heterojunction solar cells are fabricated with polymer:PC71BM as the active layer. VOC and JSC are simultaneously enhanced compared to the device performance of traditional DPP-BDT alternating polymers. A power conversion efficiency (PCE) of 8.11% was obtained, which indicates that rational utilization of backbone torsion is a promising strategy to improve the photovoltaic performance.
Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses
Zhao, Xin,Li, Runfeng,Zhou, Yang,Xiao, Mengjie,Ma, Chunlong,Yang, Zhongjin,Zeng, Shaogao,Du, Qiuling,Yang, Chunguang,Jiang, Haiming,Hu, Yanmei,Wang, Kefeng,Mok, Chris Ka Pun,Sun, Ping,Dong, Jianghong,Cui, Wei,Wang, Jun,Tu, Yaoquan,Yang, Zifeng,Hu, Wenhui
, p. 5187 - 5198 (2018/06/04)
Influenza pandemic is a constant major threat to public health caused by influenza A viruses (IAVs). IAVs are subcategorized by the surface proteins hemagglutinin (HA) and neuraminidase (NA), in which they are both essential targets for drug discovery. While it is of great concern that NA inhibitor oseltamivir resistant strains are frequently identified from human or avian influenza virus, structural and functional characterization of influenza HA has raised hopes for new antiviral therapies. In this study, we explored a structure-activity relationship (SAR) of pinanamine-based antivirals and discovered a potent inhibitor M090 against amantadine-resistant viruses, including the 2009 H1N1 pandemic strains, and oseltamivir-resistant viruses. Mechanism of action studies, particularly hemolysis inhibition, indicated that M090 targets influenza HA and it occupied a highly conserved pocket of the HA2 domain and inhibited virus-mediated membrane fusion by locking the bending state of HA2 during the conformational rearrangement process. This work provides new binding sites within the HA protein and indicates that this pocket may be a promising target for broad-spectrum anti-influenza A drug design and development.
HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE
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Page/Page column 195, (2009/02/10)
To provide a novel compound which has S1P receptor agonistic activity, exhibits excellent immunosuppressing effect, gives less adverse side effects, and can be orally administered. The invention provides a compound represented by general formula (I) (wherein A is a single bond, -O-, or - CH2-; R1 represents a hydrogen atom or a C1-C6 alkyl group, and V represents any one group selected from among the following groups (1) to (3) : (1) -G1-, (2) -G2-N(R2) -G3-, and (3) a group represented by formula 2, wherein each of Z1 and Z2 represents a hydrogen atom or a C1-C6 alkyl group, Z3 represents a hydrogen or the like, Q represents -CH2-O- or the like, and Y represents a group represented by foumula 3, a salt thereof, or a solvate thereof.
