178955-39-0Relevant academic research and scientific papers
Synthesis of P-chiral enephosphonic acid derivatives
Grison, Claude,Comoy, Corinne,Chatenet, David,Coutrot, Philippe
, p. 83 - 97 (2002)
An efficient and convenient synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidenediphosphorylation of nucleophiles followed by a Horner-Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a twostep reaction sequence. Regioselectivity of Horner-Emmons reaction and 31P-NMR study of diphosphorylated anions were described.
