178972-34-4

Upstream product

• 27687-14-5 trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid 
• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 172348-63-9 tert-butyl (((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)carbamate 

Downstream Products

• 749866-16-8 4-amino-2-[trans-(4-aminomethylcyclohexyl)methyamino]quinazoline 
• 166168-16-7 trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester 
• 509142-38-5 {4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-carbamic acid tert-butyl ester 
• 192323-09-4 {4-[(4-amino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-carbamic acid tert-butyl ester 
• 853799-80-1 [4-(quinazolin-2-ylaminomethyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester 
• 192323-08-3 N-tert-butoxycarbonyl-trans-4-(aminomethyl)cyclohexanemethyl azide 

Relevant academic research and scientific papers

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

A series of 4-(dimethylamino)quinazoline based antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. This series was derived from a lead compound, AR129330, identified by HTS of a GPCR-directed library using a functional assay with a constitutively activated (CART) form of the receptor. The preliminary optimization resulted in the identification of compounds 20, 21, and 23.