178977-45-2

Upstream product

• 178977-53-2 (E)-(S)-5-Hydroxy-6-oxo-8-phenyl-oct-2-en-7-ynoic acid tert-butyl ester 
• 178977-41-8 (2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propanoylamino]propanoyloxy]-4-methylpentanoic acid 
• 178977-52-1 (E)-(S)-6-Oxo-8-phenyl-5-(tetrahydro-pyran-2-yloxy)-oct-2-en-7-ynoic acid tert-butyl ester 
• 178977-38-3 3-[(2R)-(tert-butoxycarbonylamino)-3-(4-methoxyphenyl)propanoylamino]propanoic acid 
• 179093-53-9 (4S,5R)-4-Hydroxy-5-phenylethynyl-dihydro-furan-2-one 
• 536-74-3 phenylacetylene 
• 68856-96-2 N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 

Relevant academic research and scientific papers

Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

Several members of the Cryptophycin family were synthesised using a straightforward convergent approach. The proposed synthetic route was used to prepare novel analogs of Cryptophycins A and B in which the benzylic epoxide moiety was replaced by alternate electrophilic functions. The effect of these modifications on cytotoxic activity was determined on several tumor cell lines.