1790-74-5 Usage
Functionality
Central nervous system stimulant
Consumption
Most widely consumed psychoactive substance in the world
Sources
Found in coffee, tea, energy drinks, and some medications
Mechanism of Action
Blocks the action of adenosine, a neurotransmitter causing relaxation and drowsiness
Effects
Increases alertness and improves cognitive function
Additional Properties
Diuretic, stimulates urine release, helps prevent and treat fluid retention
Potential Side Effects
Jitteriness, insomnia, increased heart rate (with excessive consumption)
Consumption Recommendation
Moderate intake to avoid negative side effects
Check Digit Verification of cas no
The CAS Registry Mumber 1790-74-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,9 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1790-74:
(6*1)+(5*7)+(4*9)+(3*0)+(2*7)+(1*4)=95
95 % 10 = 5
So 1790-74-5 is a valid CAS Registry Number.
1790-74-5Relevant articles and documents
Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein
Yan, Bo,Liu, Lei,Huang, Shaoqiang,Ren, Yan,Wang, Huayi,Yao, Zhenglin,Li, Lin,Chen, She,Wang, Xiaodong,Zhang, Zhiyuan
, p. 3637 - 3640 (2017)
We report the development of novel Mixed Lineage Kinase Domain-Like protein (MLKL) inhibitors with single nanomolar potency (compound 15 is also named as TC13172). Using the converting biochemistry to chemistry activity-based protein profiling (BTC-ABPP) method, we were able to determine that the inhibitors covalently bind to Cysteine86 (Cys-86) of MLKL. This is the first example of the use of LC-MS/MS to identify the binding site of an MLKL inhibitor. The novel MLKL inhibitors provide powerful tools to study the biological function of MLKL and demonstrate that MLKL should be viewed as a druggable target.
