179060-39-0Relevant academic research and scientific papers
A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds
Firth, James D.,Craven, Philip G. E.,Lilburn, Matthew,Pahl, Axel,Marsden, Stephen P.,Nelson, Adam
, p. 9837 - 9840 (2016/08/04)
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels-Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
Tetrahydrobenzindole derivatives
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, (2008/06/13)
Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.
