179078-19-4

Upstream product

• 179077-82-8 ((R)-1-Thiazol-2-yl-but-3-enyl)-[(1R,4R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-(2E)-ylidene]-amine 
• 179077-86-2 (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-1-thiazol-2-yl-but-3-enylimino]-bicyclo[3.1.1]heptan-2-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 170899-08-8 N-(tert-butoxycarbonyl)-D-allylglycine 
• 367250-91-7 (1R)-[1-(methoxy-methylcarbamoyl)-but-3-enyl]-carbamic acid tert-butyl ester 
• 179077-99-7 ((R)-1-Thiazol-2-yl-but-3-enyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Analogues of bleomycin: Synthesis of conformationally rigid methylvalerates

(equation presented) Several conformationally rigid analogues of the methylvalerate subunit contained within the linker domain of the antitumor antibiotic bleomycin have been prepared. These compounds have been protected in a fashion suitable for the solid-phase synthesis of bleomycin. Bleomycin congeners containing these analogues should facilitate a more detailed understanding of the nature of the conformational bend that the methylvalerate moiety is thought to impart to the natural product.

Alkylation of camphor and pinanone imines of 2-(aminomethyl)thiazole. Enantioselective synthesis of 2-(1-aminoalkyl)thiazoles

A method is described for the enantioselective synthesis of 2-(1-aminoalkyl)thiazoles 6 via stereoselective alkylation of the carbanions of (+)-(R)-camphor and (-)-(1S, 2S, 5S)-2-hydroxypinan-3-one imines 2 and 3 derived from 2-(aminomethyl)thiazole (2-AMT, 1). Compounds 6 serve as α-amino aldehyde precursors via thiazolyl-to-formyl conversion.