179116-05-3Relevant academic research and scientific papers
INHIBITORS OF LEUCINE RICH REPEAT KINASE 2
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, (2019/02/02)
The present invention relates to novel compounds that inhibit LRRK2 kinase activity, to processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
Mechanistic studies of highly enantio-and diastereoselective aza-petasis-ferrier rearrangement catalyzed by chiral phosphoric acid
Terada, Masahiro,Komuro, Takazumi,Toda, Yasunori,Korenaga, Toshinobu
supporting information, p. 7044 - 7057 (2014/06/09)
The precise mechanism of the highly anti-and enantioselective aza-Petasis-Ferrier (APF) rearrangement of hemiaminal vinyl ethers catalyzed by a chiral phosphoric acid was investigated by undertaking experimental and theoretical studies. The APF rearrangem
