179186-57-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 179186-56-2 {4-[(4-Benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-[4-(4-hydroxy-butylamino)-butyl]-carbamic acid tert-butyl ester 
• 179186-53-9 Toluene-4-sulfonic acid 4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl ester 

Downstream Products

• 179186-58-4 (4-Benzyloxycarbonylamino-butyl)-{4-[tert-butoxycarbonyl-(4-{tert-butoxycarbonyl-[4-(4-hydroxy-butylamino)-butyl]-amino}-butyl)-amino]-butyl}-carbamic acid tert-butyl ester 
• 179186-59-5 4-[(4-{[4-({4-[(4-Benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyric acid 

Relevant academic research and scientific papers

A microgonotropen pentaaza pentabutylamine and its interactions with DNA

The central pyrrole of a site-selective DNA minor groove binding tripyrrole peptide (1) has been attached to N-protected pentaazapentacosanoic acid (17) via a (CH2)3 NHCO (CH2)3 linker to provide 19, subsequent deprotection provided the pentaaza microgonotropen 4. The polyamine moiety of 4 reaches out of the minor groove and binds to the phosphate backbone of DNA. We find when employing Hoechst 33258 (Ht) as a fluorescent titrant to follow binding of 4 to the hexadecameric duplex d(GGCGCAAATTTGGCGG)/(CCGCCAAATTTGCGCC) and by 1H NMR titration of d(CGCAAATTTGCG)2 with 4 that the latter forms both 1:1 and 2:1 dsDNA complexes. Certain aspects of the structure of 4:d(CGCAAATTTGCG)2 complex derived via 1H NMR are discussed. The electrophoretic mobilities of φX-174 DNA digested with HaeIII endonuclease restriction fragments complexed to 4 shows that the latter brings about a greater conformational change in the DNA fragments than observed previously with other microgonotropens.