179244-72-5Relevant academic research and scientific papers
Nickel-Catalyzed Decarboxylative Coupling of Alkynyl Carboxylates with Aryl Tosylates and Mesylates
Howard, Anna,Klemann, Samantha,Kolling, Sarah,Little, Katrina,Plasek, Erin,Kalyani, Dipannita
, p. 1603 - 1610 (2019/03/26)
A method for the nickel-catalyzed coupling of alkynyl carboxylates or acids with aryl tosylates and mesylates is described. Electronically varied carboxylates and aryl electrophiles participate in these transformations to afford the desired diarylalkyne p
Single electron transfer-induced coupling of alkynylzinc reagents with aryl and alkenyl iodides
Okura, Keisho,Kawashima, Hitomi,Tamakuni, Fumiko,Nishida, Naoya,Shirakawa, Eiji
supporting information, p. 14019 - 14022 (2016/12/09)
Alkynylzinc reagents were found to undergo coupling with aryl and alkenyl iodides to give arylalkynes and alkenylalkynes without the aid of transition metals. The coupling reaction proceeds through a single electron transfer mechanism, where a substoichiometric amount of a phosphine works as an indispensable activator.
Bis(pyrazolyl)methane Copper Complexes as Robust and Efficient Catalysts for Sonogashira Couplings
Moegling, Julian,Benischke, Andreas D.,Hammann, Jeffrey M.,Vepek, Nynke A.,Zoller, Florian,Rendenbach, Bettina,Hoffmann, Alexander,Sievers, Holger,Schuster, Michael,Knochel, Paul,Herres-Pawlis, Sonja
, p. 7475 - 7483 (2016/01/25)
A series of bis(pyrazolyl)methane copper complexes were found to catalyze a fast palladium-free Sonogashira coupling reaction of several iodoarenes with terminal alkynes such as phenylacetylene, propargyl benzyl ether, and (tert-butyl-dimethyl)silylacetyl
Palladhim-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide
Kim, Hyunseok,Lee, Phil Ho
supporting information; experimental part, p. 2827 - 2832 (2010/03/26)
Palladium-catalyzed decarboxylative sp-sp2 cross-coupling reactions of aryl and vinyl halides and triflates with α,β-ynoic acids using silver oxide have been developed. A variety of α,β-ynoic acids were readily decarboxylated in the presence of
PIPERAZINE METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) NEGATIVE ALLOSTERIC MODULATORS FOR ANXIETY/DEPRESSION
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Page/Page column 46, (2009/12/27)
The present teachings relate to piperazine metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators having Formula (I); wherein the constituent variables are as defined herein. The present teachings further relate to methods for the preparation of the compounds, and to methods for using the compounds for treatment of diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety.
Insights into Sonogashira cross-coupling by high-throughput kinetics and descriptor modeling
An Der Heiden, Markus R.,Plenio, Herbert,Immel, Stefan,Burello, Enrico,Rothenberg, Gadi,Hoefsloot, Huub C. J.
experimental part, p. 2857 - 2866 (2009/05/07)
A method is presented for the high-throughput monitoring of reaction kinetics in homogeneous catalysis, running up to 25 coupling reactions in a single reaction vessel. This method is demonstrated and validated on the Sonogashira reaction, analyzing the k
ANTIBACTERIAL AGENTS
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Page 99-100, (2010/02/06)
The present invention relates to antibacterial agents that are useful for sterilization, sanitation, antisepsis, and disinfection.
