179248-59-0 Usage
Description
6,7-Dimethoxy-N-(4-phenoxyphenyl)is a potent and selective dual site Src kinase inhibitor with high affinity for both the ATPand peptide-binding sites. It is also known to inhibit VEGFR2 and c-fms tyrosine kinases at higher concentrations.
Uses
Used in Pharmaceutical Industry:
6,7-Dimethoxy-N-(4-phenoxyphenyl)is used as a Src kinase inhibitor for the treatment of lung cancers with EGF receptor abnormalities. It is a potential candidate for molecular-targeted therapy due to its ability to selectively target and inhibit the Src kinase, which plays a crucial role in cell signaling and is often dysregulated in cancer cells.
Used in Research Applications:
6,7-Dimethoxy-N-(4-phenoxyphenyl)is used as a Src inhibitor in Src kinase-mediated cell signaling studies. It helps researchers understand the role of Src kinase in various cellular processes and its potential as a therapeutic target for different diseases.
Used in Drug Development:
6,7-Dimethoxy-N-(4-phenoxyphenyl)is used in the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles have been employed as carriers for its delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Biochem/physiol Actions
Cell permeable: yes
References
1) Tian et al. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines; Biochem. 40 7084
2) Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem. J. 408 297
Check Digit Verification of cas no
The CAS Registry Mumber 179248-59-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,2,4 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 179248-59:
(8*1)+(7*7)+(6*9)+(5*2)+(4*4)+(3*8)+(2*5)+(1*9)=180
180 % 10 = 0
So 179248-59-0 is a valid CAS Registry Number.
