179258-53-8Relevant academic research and scientific papers
Design and synthesis of novel active phosphonate esters and their application in preparation of ceftriaxone
Ren, Hui-Xue,Sun, You-Min,Wu, Dao-Ji,Ma, Yong-Shan,Ying, Han-Jie,Ma, Yan
, p. 155 - 159 (2014/07/07)
For a series of active phosphonate esters, the anhydride abbreviated as ANPTA (6a) exhibits the highest reactivity in the preparation of ceftriaxone. The synthesis of ceftriaxone was optimized with the pilot-scale yield reaching 95.7%. The results were explained from the structural viewpoint and supported by analysis of the calculated Mulliken atomic charge distribution.
Diethyl chlorophosphate: An effective and convenient coupling reagent of cephalosporin derivatives
Lee, Hong-Woo,Kang, Tae Won,Cha, Kyung Hoi,Kim, Eung-Nam,Choi, Nam-Hee,Kim, Jung-Woo,Hong, Chung Il
, p. 35 - 44 (2007/10/03)
A coupling reagent, diethyl chlorophosphate (DECP) 2, was reacted with 2-(2-amino-4-thiazolyl)-2-syn-alkoxyiminoacetic acid 1 to give an active ester intermediate 3.
