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179323-61-6

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179323-61-6 Usage

Uses

5-(1-Aminoethyl)pyrimidine was used as in intermediate in the synthesis of benzimidazolone muscarinic antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 179323-61-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,3,2 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 179323-61:
(8*1)+(7*7)+(6*9)+(5*3)+(4*2)+(3*3)+(2*6)+(1*1)=156
156 % 10 = 6
So 179323-61-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3/c1-5(7)6-2-8-4-9-3-6/h2-5H,7H2,1H3

179323-61-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-pyrimidin-5-ylethanamine

1.2 Other means of identification

Product number -
Other names 1-(Pyrimidin-5-yl)ethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:179323-61-6 SDS

179323-61-6Upstream product

179323-61-6Downstream Products

179323-61-6Relevant articles and documents

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1

Casimiro-Garcia, Agustin,Allais, Christophe,Brennan, Agnes,Choi, Chulho,Dower, Gabriela,Farley, Kathleen A.,Fleming, Margaret,Flick, Andrew,Frisbie, Richard K.,Hall, Justin,Hepworth, David,Jones, Hannah,Knafels, John D.,Kortum, Steve,Lovering, Frank E.,Mathias, John P.,Mohan, Sashi,Morgan, Paul M.,Parng, Chuenlei,Parris, Kevin,Pullen, Nick,Schlerman, Franklin,Stansfield, John,Strohbach, Joseph W.,Vajdos, Felix F.,Vincent, Fabien,Wang, Hong,Wang, Xiaolun,Webster, Robert,Wright, Stephen W.

, p. 757 - 784 (2022/01/20)

A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that was used to build target confidence, concerns over the ketone moiety led to the replacement of this group. The successful replacement of this moiety was achieved with pyrimidine carboxamides derived from cyclic secondary amines that were extensively characterized using biophysical and crystallographic methods as competitive inhibitors of vanin-1. Through optimization of potency and physicochemical and ADME properties, and guided by co-crystal structures with vanin-1, 3 was identified with a suitable profile for advancement into preclinical development.

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