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  • (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

    Cas No: 179324-87-9

  • USD $ 2.0-2.0 / Gram

  • 1 Gram

  • 20 Metric Ton/Year

  • Jinan Finer Chemical Co., Ltd
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  • (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Manufacturer/High quality/Best price/In stock

    Cas No: 179324-87-9

  • USD $ 3.0-3.0 / Kilogram

  • 1 Kilogram

  • 1-100 Metric Ton/Month

  • Dayang Chem (Hangzhou) Co.,Ltd.
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  • High purity (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate CAS No.:179324-87-9

    Cas No: 179324-87-9

  • USD $ 2.0-2.0 / Kilogram

  • 1 Kilogram

  • 10 Metric Ton/Month

  • Hangzhou Think Chemical Co. Ltd
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  • Factory Supply (Ar,3As,4S,6S,7Ar)-Hexahydro-3A,8,8-Trimethyl-Alpha-(2-Methylpropyl)-4,6-Methano-1,3,2-Benzodioxaborole-2-Methanamine 2,2,2-Trifluoroacetate

    Cas No: 179324-87-9

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  • Ality Chemical Corporation
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  • High Quality 99% (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 179324-87-9 ISO Producer

    Cas No: 179324-87-9

  • USD $ 0.1-0.1 / Gram

  • 1 Gram

  • 100 Metric Ton/Year

  • Xi'an Xszo Chem Co., Ltd.
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179324-87-9 Usage


(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate is a complex organic compound with a unique molecular structure. It is characterized by its hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole core, which is further functionalized with a 2-methanamine group and a 2,2,2-trifluoroacetate moiety. (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate is a white solid and is known for its potential applications in the pharmaceutical industry, particularly as an intermediate in the synthesis of Bortezomib (B675700), a boronic acid dipeptide derivative that acts as a proteasome inhibitor.


Used in Pharmaceutical Industry:
(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate is used as an intermediate in the synthesis of Bortezomib (B675700) for its role as a proteasome inhibitor. Proteasome inhibitors are important in the development of drugs targeting various diseases, including cancer, by disrupting the cellular protein degradation pathway and leading to the accumulation of misfolded proteins, ultimately causing cell death.
As a Bortezomib intermediate, this compound contributes to the development of therapeutic agents that can potentially treat multiple myeloma, mantle cell lymphoma, and other malignancies. Its unique structure and properties make it a valuable component in the design and synthesis of novel boronic acid dipeptide derivatives with improved pharmacological profiles and enhanced efficacy in combating cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 179324-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,3,2 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 179324-87:
169 % 10 = 9
So 179324-87-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier

Product name (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetate

1.2 Other means of identification

Product number -
Other names (R)-BoroLeu-(+)-Pinanediol trifluoroacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:179324-87-9 SDS

179324-87-9Relevant articles and documents



, (2019/05/10)

A substituted boric acid compound, a pharmaceutical composition comprising same, and an application thereof. The substituted boric acid compound is a compound represented by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate, or a solvent compound thereof. The boric acid compound has proteasome inhibitory activity, good pharmacodynamic/pharmacokinetic performance, good applicability, and high safety, and can be used for preparing drugs for treating diseases related to proteasomes.

Preparation of (1R)-(S)-pinane diol-1-amino-3-methyl-butane-1-borate and a salt thereof


, (2016/10/08)

The invention discloses a method for preparing (1R)-(S)-pinanediol-1-amino-3-methylbutane-1-borate ester and a salt thereof. The method for preparing (1R)-(S)-pinanediol-1-amino-3-methylbutane-1-borate ester comprises step A and step B in the following synthetic route, wherein in the formula, X represents a halogen atom and M represents an alkali metal. (1R)-(S)-pinanediol-1-amino-3-methylbutane-1-borate ester is subjected to a salt forming reaction with an organic acid or an inorganic aid, and an acidic salt of (1R)-(S)-pinanediol-1-amino-3-methylbutane-1-borate ester is obtained. The method of the invention can help to synthesize high-purity bortezomib or other boropeptide compounds in low cost, is accord with industrial production requirements and has practical value.

Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif

Stein, Martin L.,Cui, Haissi,Beck, Philipp,Dubiella, Christian,Voss, Constantin,Krueger, Achim,Schmidt, Boris,Groll, Michael

supporting information, p. 1679 - 1683 (2014/03/21)

The ubiquitin-proteasome system (UPS) has been successfully targeted by both academia and the pharmaceutical industry for oncological and immunological applications. Typical proteasome inhibitors are based on a peptidic backbone endowed with an electrophi

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