179333-97-2Relevant academic research and scientific papers
Heterocyclic compounds and their preparation and use
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, (2008/06/13)
The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine. Synthesis, receptor affinity, and antinociceptive activity
Sauerberg, Per,Olesen, Preben H.,Sheardown, Malcolm J.,Rimvall, Karin,Th?gersen, A Henning,Shannon, Harlan E.,Sawyer, Barry D.,Ward, John S.,Bymaster, Frank P.,Delapp, Neil,Calligaro, David O.,Swedberg, Michael D. B.
, p. 109 - 116 (2007/10/03)
Conformationally constrained analogues of the potent muscarinic agonist 3-(4-(methylthio)l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine (methylthio-TZTP, 17) were designed and synthesized with the aim of (a) improving the antinociceptive selec
