179334-20-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(4-BROMOBENZENESULFONYL)PIPERAZINE is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, leveraging its versatile intermediate properties to contribute to the development of new and improved compounds.
Used in Bioactive Molecule Preparation:
4-(4-BROMOBENZENESULFONYL)PIPERAZINE is used as a reactant in the preparation of bioactive molecules, playing a crucial role in the creation of substances with potential therapeutic or biological activity.
Used in Coordination Chemistry:
4-(4-BROMOBENZENESULFONYL)PIPERAZINE is used as a ligand in coordination chemistry, enabling the formation of coordination compounds that can have specific properties and applications in various fields.
Used in Materials Science:
4-(4-BROMOBENZENESULFONYL)PIPERAZINE is used in the field of materials science for the development of polymers and advanced materials, where its unique structure and properties can contribute to the creation of innovative materials with enhanced performance characteristics.

Upstream product

• 259808-63-4 4-(4-bromobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester 
• 98-58-8 4-bromobenzenesulfonyl chloride 

Downstream Products

• 944706-82-5 C₁₀H₁₅BN₂O₄S 
• 194666-85-8 1-(4-pyrimidyl)-4-(4-bromophensulphonyl)piperazine 
• 486422-26-8 1-[4-(4-bromo-benzenesulfonyl)-piperazin-1-yl]-ethanone 
• 1233940-69-6 7-((4-(4-bromophenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol 
• 1291057-96-9 1-benzo[b]thiophen-3-yl-3-[4-(4-bromobenzenesulfonyl)piperazin-1-yl]propan-1-one hydrochloride 
• 1291141-96-2 1-benzo[b]thiophen-3-yl-3-[4-(4-bromobenzenesulfonyl)piperazin-1-yl]propan-1-one 

Relevant academic research and scientific papers

Myricetin derivative containing sulfonyl piperazine as well as preparation method and application thereof

The invention discloses a myricetin derivative containing sulfonyl piperazine as well as a preparation method and application of the myricetin derivative. The structural general formula of the myricetin derivative is shown in the specification, and n is t

Discovery of Novel Chromone Derivatives Containing a Sulfonamide Moiety as Anti-ToCV Agents through the Tomato Chlorosis Virus Coat Protein-Oriented Screening Method

A number of novel chromone derivatives containing sulfonamide moieties were designed and synthesized, and the activity of compounds against tomato chlorosis virus (ToCV) was assessed using the ToCVCP-oriented screening method. Comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were established based on the dissociation constant (Kd) values of the target compounds, and compound 35 was designed and synthesized with the aid of CoMFA and CoMSIA models. The study of affinity interaction indicated that compound 35 exhibited excellent affinity with ToCVCP with a Kd value of 0.11 μM, which was better than that of the positive control agents xiangcaoliusuobingmi (0.44 μM) and ningnanmycin (0.79 μM). In addition, the in vivo inhibitory effect of compound 35 on the ToCVCP gene was evaluated by the quantitative real-time polymerase chain reaction. ToCVCP gene expression levels of the compound 35 treatment group were reduced by 67.2%, which was better than that of the positive control agent ningnanmycin (59.5%). Therefore, compound 35 can be used as a potential anti-ToCV drug in the future.

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

IMIDAZOLYL-SUBSTITUTED BENZOPHENONE COMPOUNDS

The compounds of formula (I) in which X, Y, R1 and R2 have the meanings as given in the description are novel effective inhibitors of the inducible nitric oxide synthase.

IMIDAZOLYL-SUBSTITUTED AZABENZOPHENONE COMPOUNDS

The compounds of formula (I) in which X, Y, R1 and R2 have the meanings as given in the description are novel effective inhibitors of the inducible nitric oxide synthase.

PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to compounds of Formula (I) as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Certain substituted 1-aryl-3-piperazin-1′-yl propanones

Disclosed are compounds of formula I: wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1and Ar2independently represent aryl groups; and Y is hydrogen; o

Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease

Disclosed are compounds of formula I: STR1 or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 i

Substituted 1-aryl-3-piperazin-1'-yl propanones

Disclosed are compounds of formula I: STR1 wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydr