179411-93-9

Basic information

• Product Name: SDZ 220-581 (hydrochloride)
• Synonyms: SDZ 220-581 (hydrochloride);(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride
• CAS NO: 179411-93-9
• Molecular Formula: C16H18Cl2NO5P
• Molecular Weight: 406.197581
• Mol File: 179411-93-9.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: room temp
• Solubility: DMSO: soluble5mg/mL, clear (warmed)
• CAS DataBase Reference: SDZ 220-581 (hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: SDZ 220-581 (hydrochloride)(179411-93-9)
• EPA Substance Registry System: SDZ 220-581 (hydrochloride)(179411-93-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 179411-93-9(Hazardous Substances Data)

Usage

Biological Activity

sdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2].

references

[1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669.