179461-52-0

Basic information

• Product Name: PD 151746
• Synonyms: 3-(5-FLUORO-3-INDOLYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID;PD 151746;3-(5-fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid;PD151746 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-2-Propenoic acid;PD 151746, 96%, cell permeable, selective, calpain inhibitor
• CAS NO: 179461-52-0
• Molecular Formula: C11H8FNO2S
• Molecular Weight: 237.25
• Product Categories: Inhibitors
• Mol File: 179461-52-0.mol
• Article Data: 1

Chemical Properties

• Appearance: light orange to dark orange/
• Storage Temp.: -20°C
• Solubility: DMSO: soluble15mg/mL (clear orange solution)
• CAS DataBase Reference: PD 151746(CAS DataBase Reference)
• NIST Chemistry Reference: PD 151746(179461-52-0)
• EPA Substance Registry System: PD 151746(179461-52-0)

Safety Data

• Safety Statements: 24/25
• RIDADR: 3077
• WGK Germany: 3
• Hazardous Substances Data: 179461-52-0(Hazardous Substances Data)

Usage

Uses

PD 151746 acts as a cell-permeable calpain inhibitor which induce pertussis toxin (PTx)-sensitive chemotaxis in neutrophils and human monocytes. This results in an inhibition of inflammation.

Relevant articles and documents

ALPHA-MERCAPTOACRYLIC ACID DERIVATIVES HAVING CALPAIN INHIBITORY ACTIVITY

The invention covers a novel series of α-mercaptoacrylic acid derivatives that inhibit both calpain I and calpain II with a high affinity and selectivity. The compounds are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders, brain injury, spinal cord, and peripheral nerve injury, cardiac infarction, cataracts, inflammation, restenosis, muscular dystrophy, and platelet aggregation. Pharmaceutical compositions, methods of using processes for preparing and novel intermediates useful in the processes are also disclosed.