179471-47-7Relevant academic research and scientific papers
N,N′-bisbenzylidenebenzene-1,4-diamines and N,N′- bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors
Kiviranta, P?ivi H.,Lepp?nen, Jukka,Kyrylenko, Sergiy,Salo, Heikki S.,Lahtela-Kakkonen, Maija,Tervo, Anu J.,Wittekindt, Carsten,Suuronen, Tiina,Kuusisto, Erkki,J?rvinen, Tomi,Salminen, Antero,Poso, Antti,Wallén, Erik A. A.
, p. 7907 - 7911 (2006)
A series of N,N′-bisbenzylidenebenzene-1,4-diamine and N,N′-bisbenzylidenenaphthalene-1,4-diamine derivatives were synthesized as inhibitors for human sirtuin type 2 (SIRT2). The design of the new compounds was based on two earlier reported hits from molecular modeling and virtual screening. The most potent compound was N,N′-bis(2-hydroxybenzylidene) benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol.
