179476-89-2Relevant academic research and scientific papers
CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF
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, (2008/06/13)
The present invention relates to a cytokine production inhibitor comprising a compound of the formula [I] wherein R1is aryl or heteroaryl; B is a group of the formula (a) or (b) wherein R2is hydrogen atom, hydroxy, halogen atom and t
Therapeutic agent for osteoporosis and triazepine compound
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, (2008/06/13)
Therapeutic agents for osteoporosis comprising, as an active ingredient, a triazepine compound of the formula ?I! STR1 wherein R1 is aryl or heteroaryl; R2 is hydrogen atom, hydroxy, halogen atom or lower alkyl; R4 is hydrogen atom or halogen atom, or R2 and R4 form carbonyl combinedly together with the carbon atom to which they bond; R3 is hydrogen atom, lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, --X--Y wherein X is --(CH2)m --, --CO--, --COCH2 --, --NH--, --NHCH2 --, --CH2 NH--, --CH2 NHCO--, --OCH2 --, --(CH2)n O-- or --CH2 S-- and Y is halogen atom, cycloallyl, aryl or heteroaryl; and A is benzene ring or thiophene ring, or a salt thereof, novel triazepine compounds, and intermediate triazepine compounds for producing these triazepine compounds. The triazepine compounds of the formula ?I! have superior bone resorption-inhibitory action and are useful as therapeutic agents for osteoporosis.
