1795-95-5

Basic information

• Product Name: N-(1-phenylpropan-2-yl)benzamide
• Synonyms: benzamide, N-(1-methyl-2-phenylethyl)-
• CAS NO: 1795-95-5
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 1795-95-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 441.3°C at 760 mmHg
• Flash Point: 267°C
• Density: 1.068g/cm³
• Vapor Pressure: 5.51E-08mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: N-(1-phenylpropan-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-phenylpropan-2-yl)benzamide(1795-95-5)
• EPA Substance Registry System: N-(1-phenylpropan-2-yl)benzamide(1795-95-5)

Safety Data

• Hazardous Substances Data: 1795-95-5(Hazardous Substances Data)

Upstream product

• 60-15-1 2-amino-1-phenylpropane 
• 93-97-0 benzoic acid anhydride 
• 87669-80-5 C₁₆H₂₄ClNO₂ 
• 59903-67-2 (S)-3-Methyl-2-[1-methyl-2-phenyl-eth-(Z)-ylideneamino]-butyric acid ethyl ester 
• 87669-77-0 (S)-3-Methyl-2-(1-methyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester 
• 87669-90-7 C₁₆H₂₄ClNO₂ 
• 87670-14-2 3-Methyl-2-[(E)-1-methyl-2-phenyl-ethylimino]-butyric acid tert-butyl ester 
• 59903-78-5 (S)-2-(1-Methyl-2-phenyl-ethylamino)-propionic acid ethyl ester 
• 59903-66-1 (S)-2-[1-Methyl-2-phenyl-eth-(Z)-ylideneamino]-propionic acid tert-butyl ester 
• 87669-78-1 C₁₄H₂₀ClNO₂ 
• 87670-05-1 2-[(E)-1-Methyl-2-phenyl-ethylimino]-propionic acid ethyl ester 
• 59903-65-0 (S)-2-[1-Methyl-2-phenyl-eth-(Z)-ylideneamino]-propionic acid ethyl ester 
• 87670-06-2 3-Methyl-2-[(E)-1-methyl-2-phenyl-ethylimino]-butyric acid ethyl ester 
• 59903-79-6 (S)-2-(1-Methyl-2-phenyl-ethylamino)-propionic acid tert-butyl ester 

Downstream Products

• 38222-77-4 trans-2,5-diphenyl-4-methyl-1,3-oxazoline 
• 51650-18-1 cis-4-methyl-2,5-diphenyl-2-oxazoline 

Relevant articles and documents

Solvent-free, base-free microwave-mediated iridium-catalyzed N-alkylation of amides with alcohols

Solvent-free, base-free microwave-mediated (CpIrCl2) 2-catalyzed conditions for the N-alkylation of amides with alcohols have been developed. A series of primary and secondary alcohols have been shown to produce high yields of N-alkyl arylamides and N-alkyl alkylamides.

Ring opening of pymisyl-protected aziridines with organocuprates

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methyl-aziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson's disease. Easy on'easy off: The pymisyl group is introduced as a new protecting group for the activation of aziridines towards ring opening with organocuprates (see scheme). It is readily removed under very mild conditions with thiolates. The versatility of the approach is illustrated in a new synthesis of Selegiline, a drug marketed for the treatment of Parkinson's disease.

POLAR HYDROPHILIC PRODRUGS OF AMPHETAMINE AND OTHER STIMULANTS AND PROCESSES FOR MAKING AND USING THE SAME

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