17951-19-8

Basic information

• Product Name: JUSTICIDIN B
• Synonyms: JUSTICIDIN B;6,7-Dimethoxy-9-(1,3-benzodioxol-5-yl)naphtho[2,3-c]furan-1(3H)-one;6,7-Dimethoxy-9-(1,3-benzodioxole-5-yl)-1,3-dihydronaphtho[2,3-c]furan-1-one;Naphtho(2,3-C)furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-
• CAS NO: 17951-19-8
• Molecular Formula: C₂₁H₁₆O₆
• Molecular Weight: 364.3481
• Mol File: 17951-19-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 240°
• Boiling Point: 601.9°Cat760mmHg
• Flash Point: 266°C
• Appearance: /
• Density: 1.376g/cm³
• Vapor Pressure: 1.93E-14mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: JUSTICIDIN B(CAS DataBase Reference)
• NIST Chemistry Reference: JUSTICIDIN B(17951-19-8)
• EPA Substance Registry System: JUSTICIDIN B(17951-19-8)

Safety Data

• Hazardous Substances Data: 17951-19-8(Hazardous Substances Data)

Usage

Uses

Piscicidal agent.

InChI:InChI=1/C21H16O6/c1-23-16-7-12-5-13-9-25-21(22)20(13)19(14(12)8-17(16)24-2)11-3-4-15-18(6-11)27-10-26-15/h3-8H,9-10H2,1-2H3

Upstream product

• 28982-10-7 9-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxy-3a,4-dihydronaphtho[2,3-c]furan-1(3H)-one 
• 96264-86-7 6,7-Dimethoxy-1-(3,4-methylendioxyphenyl)-naphthalin-2,3-dicarbonsaeureanhydrid 
• 22055-22-7 diphyllin 
• 74879-20-2 1-Benzo[1,3]dioxol-5-yl-4-hydroxy-6,7-dimethoxy-naphthalene-2,3-dicarboxylic acid dimethyl ester 
• 94285-11-7 9-Benzo[1,3]dioxol-5-yl-9a-hydroxy-6,7-dimethoxy-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one 
• 131719-30-7 [(3S,4R)-4-(Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-5-oxo-tetrahydro-furan-3-yl]-(tert-butyl-dimethyl-silanyloxy)-(3,4-dimethoxy-phenyl)-acetonitrile 
• 186581-53-3 diazomethane 
• 79862-77-4 9-(1,3-benzodioxol-5-yl)-7-hydroxy-6-methoxynaphtho[2,3-c]furan-1(3H)-one 
• 76885-59-1 dimethyl 1-hydroxy-6,7-dimethoxynaphthalene-2,3-dicarboxylate 
• 93-07-2 Veratric acid 
• 95436-24-1 dimethyl 1-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxynaphthalene-2,3-dicarboxylate 
• 76885-49-9 dimethyl 6,7-dimethoxy-1,4-dihydro-1,4-epoxynaphthalene-2,3-dicarboxylate 
• 531-88-4 5,6-dimethoxyphthalide 
• 1621253-02-8 2-formyl-4,5-dimethoxy-N,N-dimethylbenzamide 

Relevant articles and documents

A Regiocontrolled Synthesis of Some Arylnaphthalide Lignans

Three arylnaphthalide lignans are synthesised by regiocontrolled transformations of Diels-Alder adducts generated from dimethyl acetylenedicarboxylate and suitable isobenzofurans.

ARYLNAPHTHALENE LIGNANS OF Haplophyllum dauricum. THE STRUCTURE OF DAURINOL

The arylnaphthalene lignans justicidin B and daurinol I have been isolated from the epigeal part of Haplophyllum dauricum (L.) G.Don.

The efficient synthesis and biological evaluation of justicidin B

A facile new synthetic method for the preparation of a Type-A 1-arylnaphthalene lactone skeleton was developed and used to synthesise justicidin B and several derivatives. Key synthesis steps included Hauser–Kraus annulation of a phthalide intermediate and Suzuki–Miyaura cross coupling between a triflated naphthalene lactone intermediate and various potassium organotrifluoroborates. With two exceptions, the derivatives showed significant inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophages. Moreover, several compounds, including justicidin B, had marked cytotoxicity towards six human tumour cell lines.

Patentiflorin A Analogs as Antiviral Agents

The present disclosure relates to patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.