179524-60-8

Basic information

• Product Name: (2,6-Difluorophenyl)methylsulphonyl chloride
• Synonyms: (2,6-Difluorophenyl)methylsulphonyl chloride;2,6-Difluorobenzylsulphonyl chloride;(2,6-Difluorophenyl)methanesulphonyl chloride;alpha-(Chlorosulphonyl)-2,6-difluorotoluene;(2,7-Difluorophenyl)methanesulphonylchloride
• CAS NO: 179524-60-8
• Molecular Formula: C₇H₅ClF₂O₂S
• Molecular Weight: 226.6282064
• Mol File: 179524-60-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.546±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2,6-Difluorophenyl)methylsulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-Difluorophenyl)methylsulphonyl chloride(179524-60-8)
• EPA Substance Registry System: (2,6-Difluorophenyl)methylsulphonyl chloride(179524-60-8)

Safety Data

• Hazardous Substances Data: 179524-60-8(Hazardous Substances Data)

Usage

General Description

(2,6-Difluorophenyl)methylsulphonyl chloride is a chemical compound with the molecular formula C7H5ClF2O2S. It is a sulphonyl chloride derivative with two fluorine atoms attached to the phenyl ring. (2,6-Difluorophenyl)methylsulphonyl chloride is commonly used as a reagent in organic synthesis, particularly in the synthesis of pharmaceuticals and agrochemicals. It can act as a building block for various organic reactions, such as nucleophilic substitution and coupling reactions. Additionally, it has applications in the production of dyes and pigments. Overall, (2,6-Difluorophenyl)methylsulphonyl chloride is an important and versatile chemical compound with a wide range of synthetic and industrial applications.

Upstream product

• 697-73-4 2,6-difluorobenzyl chloride 
• 862896-89-7 (2,6-difluorophenyl)-methanesulfonic acid 

Downstream Products

• 540524-60-5 methyl 4-({2-[5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate 
• 1032672-59-5 methyl 3-[4-({2-[5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)phenyl]propanote 
• 683813-59-4 methyl 4-{2-[5-chloro-2-(2-{[(2,6-difluorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate 

Relevant articles and documents

Palladium-Catalyzed Remote meta-Selective C-H Bond Silylation and Germanylation

Selective meta-C-H activation of arenes to date has met with a limited number of functionalizations. Expanding the horizon of meta-C-H functionalization, herein we disclose an unprecedented meta-silylation and -germanylation protocol by employing a simple nitrile-based directing template. Longer linkers between the target site and the directing template were successfully explored for meta-silylation (sp2-? and sp2-ζ). Additionally, synthetic utility was demonstrated with several postsynthetic elaborations and with a formal synthesis of TAC101, a promising drug for the treatment of lung cancer.

Indole cytosolic phospholipase A2 α inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4- dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl} benzoic acid, efipladib

The optimization of a class of indole cPLA2α inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the

Processes for the preparation of aryl-and heteroaryl-alkylsulfonyl halides

The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar—R—SO2—X, that are useful as intermediates in the preparation of pharmaceuticals.